The process flow of the liquid preparation system is divided into three parts:

1： Pipeline process design

2： Normal operation and online detection section

3： Cleaning and sterilization section

1： Pipeline process design

1. Material selection: According to the URS peak water consumption table, the Reynolds coefficient Re is greater than 10000, and the valve size and main pipe diameter at the water point are calculated

(The water point valves are all diaphragm valves, and manual diaphragm valves are generally used), the power of the pump, the model of the frequency converter selected, and the batching tank

volume

Process Overview: The system is designed with separate concentrated and concentrated tanks, dilute and diluted tanks, and corresponding breathing filters and pumps. The dilute and diluted tanks are equipped with circulating sampling and internal components

Equipped with mixing mechanism and sprinkler head. After concentration, a 0.45 μ m carbon filter is installed for decarbonization and removal of coarse particles. The tail has been designed

A liquid level control module is designed in the high-level tank to ensure uniform and continuous drug supply and prevent drug backflow. Finally, design the circulation pipeline,

The design of the circulation loop facilitates the cleaning and sterilization of the system.

2： Normal operation and online detection

1. Feeding and ingredients: The feeding is divided into injection water, raw materials, and auxiliary materials. The feeding machine is equipped with a weight sensor to determine the weight of the raw materials, which is controlled by a valve

At the same time, an appropriate amount of activated carbon is added to the concentrated tank, and the injection water is controlled by the weighing module 1 through valves (DN25, DN40),

When the weight reaches the set value, the mixing mechanism automatically runs, and the mixing time T1 is calculated based on the characteristics of the mixing mechanism

After meeting the requirements, the mixing mechanism stops, the feed valve diaphragm valve (DV5319) is opened, and at the same time, the pressure detection of pump 1 action (PI5204) is carried out,

After corresponding pressure testing of carbon filter (PI5205) and 0.45 μ m filter (PI5206). When the dilute weighing module 2 reaches the setting

When the value is set, the pump stops and the pneumatic diaphragm valve (DN40, DN25) of the injection water inlet valve is opened to the weighing module 2 until it reaches a certain level

Close the numerical value while running the mixing mechanism, set the mixing time T2, and send the material valve diaphragm valve when T2 meets the requirements

(DV5341) Connected, proceed to the next step of transmission.

2. Material transfer: The power pump 2 for material transfer after dilution is controlled by the high-level tank liquid level sensor and the weighing module 2. When the output signal

When the liquid level is high, the pump RST; when it is low, SET. When the weighing module 2 reaches a certain value, the pump stops running and uses clean gas to

The tailings are discharged into the high-level tank, which is equipped with 0.45 μ m and 0.22 μ m filters for removing coarse particles and bacteria, and corresponding pressure detection

It is a pressure gauge (PI5209, PI5210)

3. System temperature control: A jacket is installed outside the concentrated (dilute) ingredient tank to allow access through valve sanitary ball valves (BV5310, BV5311; BV5330, BV5331)

Cooling water or pure steam. Sanitary ball valves for condensate and cooling water discharge valves (BV5315, BV5314; BV5337, BV5338)

3： Cleaning and sterilization section

1. Chemical cleaning: First, put a certain amount of purified water into the concentrated (dilute) ingredient tank, then add a strong alkali conductivity meter to detect a certain concentration, and then adjust the diaphragm valve

(DV5353) Connect a heat exchanger with a hose and then separately introduce it into the concentrated ingredient tank for cyclic cleaning. After cleaning, add strong acid

After passing the neutralization conductivity test (showing neutrality), discharge to prevent contamination of the outside world by acidic or alkaline liquids.

2. Coarse washing and fine washing: First, open the diaphragm valve (DN40) and put purified water into the circulation loop to perform coarse washing on the system, and then discharge it directly. number of times

It depends on the situation. Clean the system with injection water using the same cycle.

3. Pure steam sterilization: Open the pure steam control valve, sanitary ball valve, and close the valve diaphragm valve (DV5312) to enter the breathing filter and the entire circulation circuit

Sterilization is performed, and the sterilization time is manually set.

4. Bubble detection: In order to ensure the quality of the drug, the filter configured on the transmission pipeline should be checked for bubbles before each use, and

Record to verify this production.